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KMID : 0848120090340030137
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International Journal of Oral Biology
2009 Volume.34 No. 3 p.137 ~ p.142
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The Differential Effect of Whole-body Irradiation on Morphine- and -Endorphin-Induced Antinociceptive Actions in Mice
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Kim Kyung-N.
Chung, Ki-M
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Abstract
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Whole-body -irradiation(WBI), which produces an oxidative stress, is reported to attenuate the acute antinociceptive action of morphine (a -opioid receptor agonist), but not DPLPE (a -opioid receptor agonist), in mice. Recently, we also reported that antinociceptive effect of morphine, but not -endorphin (a novel -opioid receptor agonist), was attenuated by oxidative stress. These findings prompted us to investigate the effect of WBI on the antinociception of morphine and -endorphin in mice. Mice were exposed to WBI (5 Gy) from a gamma-source and tested 2 hours later for antinociception produced by intracerebroventricular administration of morphine or -endorphin using the hot water tail-immersion and the writhing tests. WBI significantly attenuated the antinociception produced by morphine only in the hot water tail-immersion test, whereas the antinociception of -endorphin was significantly potentiated by WBI in both tests. These results demonstrate a differential sensitivity of - and -opioid receptors to WBI, and support the hypothesis that morphine and -endorphin administered supraspinally produce antinociception by different neuronal mechanisms.
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KEYWORD
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Antinociception, -Endorphin, Morphine, Whole-body -irradiation, Mouse
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